IMO, if you are concerned about fuel economy, you need to stick with a 4 cylinder Accord. We bought a 2005 EX-L 4 cylinder in August and we are very pleased with it.
It is my wife's car. She used to have a 2003 Chevy Trailblazer EXT with an I-6. Horrible gas mileage (~13 to 14 in town, no better than 19 hwy), horrible power (as in NONE) and it was very noisy.
The Honda has more power, about twice the fuel mileage and is QUIET.
I was very, very impressed with the 4 cylinder. I think she is getting 24-25 in town and 33+ highway driving.
I bought a 1995 EX 4 cylinder 5 speed two months ago, 133k miles on it and got 33 mpg on mostly highway bringing it back home on the 130 mile trip. Dirty oil, air filter and what looked like the original plugs. All three got replaced within an hour of being home.
I am getting 24 mpg in town (we climb a decent hill for 3/4 of a mile or more atleast once a day), and over 33 on the highway.
And I parked my 2000 Chevy Silverado extended cab with a 285 HP 5300 V8 that will scream.